The Best Vertical Mouse

Wrist pain is a common issue for anyone who spends long hours using a traditional mouse. Over time, this can lead to discomfort or even conditions like carpal tunnel syndrome. Switching to a vertical mouse can significantly improve your ergonomic setup and reduce strain.

If you’re new to vertical mice, the transition can feel unfamiliar, but the right one makes all the difference. In this guide, we’ve rounded up the best vertical mice to help you work or game more comfortably and protect your wrists in the long run.

Logitech MX

Best Overall Option

Designed to reduce wrist strain and improve comfort, the Logitech MX Vertical features a natural handshake position, durable build, and versatile connectivity in a sleek, ergonomic package.

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The Logitech MX Vertical Wireless Mouse is built with comfort and ergonomics in mind. Its unique vertical design puts your hand in a natural handshake position, which helps ease wrist and forearm strain. The 57° angle is specifically designed to keep your posture more relaxed without taking away from precision or control. On top of that, the textured rubber surface gives it a steady, natural grip that feels secure even during long hours of use.

Performance-wise, the MX Vertical comes with a 4000 DPI high-precision sensor, which means you’ll move your hand a lot less than with a standard mouse. Less movement equals less fatigue, especially if you spend most of your day at the computer. There’s also a handy cursor speed switch that lets you adjust DPI levels on the fly, making it easy to switch between quick navigation and precise control.

It’s also flexible when it comes to connectivity. You can use Bluetooth, Logitech’s Unifying Receiver, or plug in with USB-C, and it works across Windows, macOS, iPadOS, ChromeOS, and Linux. With a wireless range of up to 10 meters, you won’t have to worry about staying tethered to your desk.

Battery life is another strong point. A full charge lasts up to four months, and if you’re running low, a quick one-minute charge gives you about three hours of use. It’s solidly built with durable materials and even comes in FSC-certified packaging, which is a nice touch for sustainability.

All in all, the Logitech MX Vertical is a great choice for anyone dealing with wrist discomfort or just wanting a more ergonomic setup. It’s designed for medium to large right hands and combines comfort, build quality, and performance in a way that makes it worth the investment.

Logitech Lift

Second Best Option

The Logitech Lift is designed for small to medium hands and provides a comfortable, natural grip. Its quiet buttons, smooth scroll wheel, and multiple connection options make it a smart pick.

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The Logitech Lift is a compact, well-designed vertical mouse that delivers an excellent balance of ergonomics, comfort, and day-to-day usability. Its curved form encourages a natural handshake position, which helps reduce wrist strain and supports a healthier posture over long work sessions. The soft-touch finish feels pleasant in the hand, while the tactile scroll wheel and responsive buttons make navigation smooth and precise. Designed with small to medium hands in mind, it fits comfortably without the bulk of larger vertical mice, making it especially approachable for first-time users.

One area where the Lift differs from higher-end options is its power source. Instead of a built-in rechargeable battery, it runs on a single replaceable AA battery. While this may seem less convenient, the battery life is impressive, lasting up to two years before a replacement is needed. Connectivity is versatile, offering both Bluetooth and the included Logi Bolt USB receiver, with the option to store the receiver inside the mouse when not in use. Bluetooth performance is generally reliable for everyday tasks, though the USB receiver provides smoother, more consistent tracking.

The Lift also includes six easy-to-reach buttons that are quiet and responsive. Its design naturally positions the fingers for comfort, with some users preferring to click with their ring finger while resting their middle finger on the scroll wheel. Logitech’s Options+ software allows customization of button functions and pointer speed, though many will find the default setup intuitive and effective out of the box.

Another strength of the Lift is its ability to pair with up to three devices at once, making it easy to switch between a laptop, desktop, or tablet. This flexibility, combined with its lightweight feel and durable construction, adds to its value as an everyday productivity tool. While it may not have the steep angle or size of other vertical mice, the gentler 57-degree tilt makes it easier to adapt to and more comfortable for average hands.

Overall, the Logitech Lift is a thoughtfully designed vertical mouse that offers strong ergonomics, excellent versatility, and long-lasting performance. It is a standout option for users with small to medium hands who want to reduce wrist strain without overspending, making it one of the most practical ergonomic mice available today.

Anker 2.4G

Best Budget Option

The Anker 2.4G provides solid ergonomic support at an affordable price, featuring a comfortable vertical design, responsive optical tracking, and simple plug-and-play setup.

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The Anker 2.4G Wireless Vertical Ergonomic Optical Mouse is one of the most affordable ways to experience the benefits of an ergonomic mouse. Its tall vertical shape encourages a handshake-style grip that reduces strain on the wrist and forearm, making it a practical option for users dealing with discomfort from repetitive stress injuries or carpal tunnel syndrome. Even though it is not the newest model on the market, it continues to stand out for delivering comfort and consistent performance at a very accessible price point.

This mouse is best suited for users with medium to large hands, offering a roomy grip that feels stable during long sessions. The design helps minimize unnecessary wrist movement, which in turn promotes better alignment and reduces fatigue. The build quality is solid for its price range, with a design that prioritizes support and function over flash, making it a straightforward and reliable choice for everyday productivity.

Performance is handled by an optical sensor that tracks well on most surfaces, including glass, which adds flexibility in different work setups. While the button placement can feel a bit unusual at first, especially for those with smaller hands, the layout becomes intuitive with use. The mouse is powered by standard batteries and connects via a 2.4GHz wireless receiver, providing dependable connectivity without the need for additional software.

At the end of the day, the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse remains one of the best entry-level options for users who want the ergonomic benefits of a vertical design without spending a premium. It combines comfort, reliable tracking, and ease of use into a budget-friendly package that continues to be a popular pick for those seeking healthier, more natural hand positioning.

Lenovo Go

Affordable Ergonomic Option

The Lenovo Go features an ergonomic vertical grip, textured sides for control, and reliable wireless connectivity, making it a solid budget-friendly choice for reducing wrist strain.

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The Lenovo Go Vertical Mouse brings a different take on ergonomic design with a more minimalist approach. Instead of the steeper angles and heavy sculpting seen on other vertical mice, it uses a gentler 45-degree slant that still encourages a healthier wrist position. The unique cork-like texture gives it a comfortable, natural feel in the hand, while its compact size makes it lightweight and easy to carry, fitting well into smaller workspaces.

In terms of performance, the mouse is equipped with a Blue optical sensor that supports up to 2,400 DPI. This ensures smooth tracking across a variety of surfaces, making it suitable for everyday productivity. It also works with Lenovo’s Unified Pairing Dongle, allowing you to connect multiple Lenovo accessories with a single receiver, which helps reduce USB clutter and keeps your setup streamlined.

While the design is effective at reducing wrist strain, the smaller form factor may not suit users with larger hands, as it lacks the more contoured grip of bulkier vertical mice. The absence of advanced customization software also means users won’t have the same flexibility in remapping buttons or adjusting settings compared to higher-end models. However, the simplicity can be seen as a benefit for those who just want a straightforward, no-frills ergonomic mouse.

The Lenovo Go Vertical Mouse is a solid choice for those who want a stylish, compact, and easy-to-use alternative to traditional vertical mice. Its minimalist shape, modern performance features, and comfortable texture make it well-suited for small to medium hands and for anyone looking for a lightweight ergonomic solution without unnecessary complexity.

Choosing the best vertical mouse comes down to comfort, build quality, and how well it supports a more natural wrist position throughout the day. In our testing, we paid close attention to how each mouse affected wrist fatigue during extended use, as well as how satisfying the clicks felt, the responsiveness of the scroll wheel, and the quality of each brand’s software. While some models leaned toward premium features and customization, others focused more on simplicity and affordability.

No matter your hand size or preferences, you can’t go wrong with any of the picks on this list. That said, our team especially appreciated the Logitech Lift and Logitech MX Vertical for their combination of thoughtful ergonomics, solid build quality, and everyday performance.