Wrist pain is a common issue for anyone who spends long hours using a traditional mouse. Over time, this can lead to discomfort or even conditions like carpal tunnel syndrome. Switching to a vertical mouse can significantly improve your ergonomic setup and reduce strain.
If you’re new to vertical mice, the transition can feel unfamiliar, but the right one makes all the difference. In this guide, we’ve rounded up the best vertical mice to help you work or game more comfortably and protect your wrists in the long run.
Logitech MX Vertical
Best Overall Vertical Mouse
Designed to reduce wrist strain and improve comfort, the Logitech MX Vertical features a natural handshake position, durable build, and versatile connectivity in a sleek, ergonomic package.
Buy on AmazonThe Logitech MX Vertical Wireless Mouse is a great option for users seeking comfort and ergonomic support during long work sessions. Its unique vertical design positions your hand in a natural handshake posture, reducing muscle strain and improving wrist alignment. While its shape may look unconventional, it’s purpose-built for comfort, allowing users to navigate smoothly without applying unnecessary pressure or tension.
Constructed with durable hard plastic, the MX Vertical is built to last and feels solid in the hand. It offers multiple connectivity options including Bluetooth, USB-C, and Logitech’s Unifying Receiver, which makes it highly adaptable across different setups. The battery life is impressive as well, lasting up to four months on a single charge. While its price point is on the higher side, the combination of comfort, build quality, and flexibility makes it a strong investment for anyone serious about reducing wrist pain and improving their workflow.
Logitech Lift
Second Best Option
The Logitech Lift is designed for small to medium hands and provides a comfortable, natural grip. Its quiet buttons, smooth scroll wheel, and multiple connection options make it a smart pick.
Buy on AmazonThe Logitech Lift stands out as a comfortable, thoughtfully designed vertical mouse that strikes a balance between ergonomics and everyday usability. It’s the best vertical mouse we’ve used, especially for small to medium hands, and offers excellent build quality without breaking the bank. The curved shape supports a more natural handshake position, helping to reduce wrist strain over long periods of use. Soft-touch materials provide a pleasant grip, while the tactile scroll wheel and responsive buttons contribute to a satisfying overall experience.
One of the only drawbacks is that it runs on a replaceable AA battery rather than offering a built-in rechargeable option. Additionally, while Bluetooth performance is generally fine for basic tasks, users may notice slightly laggy tracking compared to using the included USB receiver. Still, for general productivity, these limitations are minor. With nearly 11,000 Amazon reviews averaging 4.5 stars, the Logitech Lift has earned high marks for comfort, functionality, and value, making it a strong second pick for anyone in the market for an ergonomic vertical mouse.
Anker 2.4G Vertical Ergonomic
Best Budget Vertical Mouse
The Anker 2.4G provides solid ergonomic support at an affordable price, featuring a comfortable vertical design, responsive optical tracking, and simple plug-and-play setup.
Buy on AmazonThe Anker 2.4G Wireless Vertical Ergonomic Optical Mouse delivers excellent value for users seeking an ergonomic upgrade without a high price tag. Its tall, vertical design encourages a more natural hand position, helping to reduce strain from conditions like RSI or carpal tunnel syndrome. Despite being an older model, it remains a popular choice for its comfort, ease of use, and consistent performance.
Ideal for users with larger hands, the mouse offers a roomy grip and minimizes wrist movement during use. It features an optical sensor that performs well on most surfaces, including glass, making it a practical option for various work environments. While the button placement may feel unconventional, especially for those with smaller hands, the overall build quality and ergonomic benefits make it one of the best budget vertical mice available.
Lenovo Go Vertical Mouse
Affordable Ergonomic Pick
The Lenovo Go features an ergonomic vertical grip, textured sides for control, and reliable wireless connectivity, making it a solid budget-friendly choice for reducing wrist strain.
Buy on AmazonThe Lenovo Go Vertical Mouse takes a slightly different approach to ergonomic design, offering a minimalist, angled grip that sets it apart from more sculpted vertical mice. Its 45-degree slant and unique cork-like texture provide a comfortable resting position for the hand, while its compact size makes it a lightweight, space-saving option. With a Blue optical sensor, up to 2,400 DPI, and support for Lenovo’s Unified Pairing Dongle, it still delivers modern performance features despite the untraditional build.
Although its shape may feel less contoured than other vertical mice, it’s still designed to reduce wrist strain during long work sessions. However, the compact form factor may not be ideal for users with larger hands. The lack of advanced customization software also makes it less appealing for power users. Still, with over 6,900 Amazon reviews averaging 4.4 stars, the Lenovo Go Vertical Mouse is a solid option for those who want a streamlined, stylish alternative to the more conventional ergonomic designs.
Choosing the best vertical mouse comes down to comfort, build quality, and how well it supports a more natural wrist position throughout the day. In our testing, we paid close attention to how each mouse affected wrist fatigue during extended use, as well as how satisfying the clicks felt, the responsiveness of the scroll wheel, and the quality of each brand’s software. While some models leaned toward premium features and customization, others focused more on simplicity and affordability.
No matter your hand size or preferences, you can’t go wrong with any of the picks on this list. That said, our team especially appreciated the Logitech Lift and Logitech MX Vertical for their combination of thoughtful ergonomics, solid build quality, and everyday performance.